How fast does PureRawz ship LGD-4033 and where does it originate?

PureRawz dispatches all USA domestic LGD-4033 orders within 1 business day. All product is manufactured and shipped from within the United States, eliminating international transit delays and customs inspection risk. MedChemExpress is headquartered in China, with US warehouse stock subject to availability. Behemothlabz ships domestically from the USA. PureRawz matches domestic ship speed while adding lot-verified dual COA documentation no capsule or liquid competitor currently provides.

Ligandrol (LGD-4033)

Price range: $34.41 through $108.20

Earn 34 – 185 points upon purchasing this product.

✅ 99% Purity – Third-Party Tested

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SKU: N/A Category: Sarms

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Buy LGD-4033 (Ligandrol) ≥99% HPLC + Dual COA | PureRawz USA

⚠ RESEARCH USE ONLY: LGD-4033 (Ligandrol) is sold exclusively for in vitro and in vivo laboratory research. Not for human consumption, veterinary use, or therapeutic application. For qualified researchers only.

≥99% HPLC PURITY

DUAL COA: HPLC + LAL ENDOTOXIN

UNIQUE LOT # EVERY VIAL

USA MADE · 3RD PARTY TESTED

SHIPS 1 BUSINESS DAY

Buy LGD-4033 (Ligandrol)
≥99% HPLC · Dual COA · USA Made

LGD-4033 (Ligandrol, VK5211) has the highest androgen receptor binding affinity of any known non-steroidal SARM at Ki ≈ 1 nM — making documentation integrity non-negotiable. MedChemExpress lists 99.93% purity but locks QC reports behind a contact form and publishes no LAL endotoxin data. Behemothlabz shows COA images on their capsule page without a stated purity figure and without any endotoxin certificate. PureRawz supplies ≥99% HPLC-verified LGD-4033 backed by an independent LAL endotoxin report on every unique lot, shipped from the USA in 1 business day with instant documentation your lab can verify and cite.

≥99% HPLC Purity
LAL Endotoxin Tested
Unique Lot Per Vial
USA Manufactured
No Rx Required

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Dispatched within 1 business day · USA domestic only · Tracking provided on shipment

Technical Data

Full Specifications

Comprehensive compound data for LGD-4033 as supplied by PureRawz. Batch-specific analytical values are documented on each COA.

Compound Name	LGD-4033 (Ligandrol, VK5211, VK-5211)
Common Synonyms	Ligandrol; VK5211; VK-5211; LGD4033; 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Molecular Formula	C₁₄H₁₂F₆N₂O
Molecular Weight	338.25 g/mol
CAS Number	1165910-22-4
HPLC Purity	≥99% (HPLC — UV detection, per-lot)
Endotoxin Status	LAL Endotoxin Tested — Certificate Provided (Dual COA)
Androgen Receptor Ki	~1 nM — highest AR affinity among non-steroidal SARMs
Physical Form	Crystalline solid (white to off-white powder)
Solubility	DMSO: ~10 mg/ml · Ethanol: ~5 mg/ml · Water: <0.1 mg/ml (practically insoluble) · In vivo vehicle: 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% saline → ~1 mg/ml
Storage Conditions	–20°C solid, desiccated, sealed from light and moisture · Reconstituted stocks: –20°C (1 month) or –80°C (6 months)
Stability (Solid)	≥3 years at –20°C · Avoid repeated freeze-thaw of reconstituted solutions
Lot Traceability	Unique lot number per vial · Full dual COA retrievable at officialpurerawz.us/verify
Manufacturing Location	United States of America · Third-party analytical verification
Shipping Speed	Dispatched within 1 business day · USA domestic only
Intended Use	In vitro and in vivo laboratory research only · Not for human or veterinary use
Prescription Required	No · Research purchase, no Rx needed in USA
IUPAC Name	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Documentation

Dual Certificate of Analysis

Two independent analytical certifications are issued for every PureRawz LGD-4033 lot — each uniquely tied to your vial's lot number, not a shared batch document.

COA 01

HPLC Purity Certificate

High-Performance Liquid Chromatography with UV detection is the industry benchmark for quantifying SARM purity. PureRawz HPLC analysis generates a full chromatogram with retention time confirmation and peak purity assessment against certified reference standards — all performed on your specific production lot, not a population representative.

Purity ≥99% guaranteed on every lot — a minimum floor, not an average
Full chromatogram retrievable via /verify for your exact lot number — no form submission required
Compound identity confirmed by retention time against certified LGD-4033 reference
MedChemExpress: 99.93% listed, but QC report requires a contact form request — no instant public access

✗ Behemothlabz capsule page: no stated purity % · COA images shown but no per-lot public portal

COA 02

LAL Endotoxin Certificate

The Limulus Amebocyte Lysate (LAL) assay is the FDA-recognized standard for detecting bacterial lipopolysaccharide (endotoxin) contamination. HPLC cannot detect endotoxins under any conditions. A compound can achieve 99.93% HPLC purity and still contain nanogram-level LPS that activates TLR4, drives NF-κB nuclear translocation, and floods assay media with IL-6, TNF-α, and IL-1β — completely invalidating AR pathway, anabolic, anti-apoptotic, and bone metabolism research.

LAL endotoxin result expressed in EU/ml — per-lot report included with every PureRawz order
Critical for any cell-based AR agonism, caspase, apoptosis, or bone microstructure study
Suitable for IRB, IACUC, and institutional biosafety committee documentation
Prevents TLR4-driven false-positive cytokine and inflammatory pathway confounds

✗ MedChemExpress: no LAL endotoxin data on product page · ✗ Behemothlabz: no endotoxin certificate listed

Pharmacology

Mechanism of Action

LGD-4033 is the highest-affinity non-steroidal SARM characterized to date (AR Ki ≈ 1 nM). Six primary research-documented pharmacological pathways are described below.

Ultra-High Affinity AR Agonism (Ki ≈ 1 nM)

LGD-4033 binds the androgen receptor with a Ki of approximately 1 nM — an order of magnitude more potent than most non-steroidal SARMs including Ostarine (Ki 3.8 nM) and RAD-140 (Ki 7 nM). This exceptional AR affinity translates to anabolic efficacy at very low doses (0.1–1 mg/kg) in preclinical muscle and bone models, making it a primary reference compound for SARM potency benchmark studies.

↗ PubMed: Basaria S et al., 2013 (PMID 24171373)

Selective Muscle and Bone AR Activation

LGD-4033 produces potent agonist activity at the androgen receptor in skeletal muscle and bone tissue while demonstrating reduced androgenic activity in reproductive organs compared to testosterone. This tissue selectivity is mechanistically driven by differential co-activator recruitment at the AR ligand-binding domain upon LGD-4033 versus DHT binding, resulting in distinct nuclear transcriptional programmes.

↗ PubMed: Basaria S et al., 2013 (PMID 24171373)

PI3K/Akt/mTOR Anabolic Signalling

AR activation by LGD-4033 in skeletal myocytes initiates the PI3K → Akt → mTOR axis, driving phosphorylation of S6K1 and inactivation of 4E-BP1 to promote cap-dependent translation of myofibrillar proteins. Additionally, LGD-4033 has been shown to inhibit muscle breakdown by suppressing the ubiquitin-proteasome proteolytic pathway and reducing oxidative stress biomarkers in cisplatin-induced toxicity models.

↗ PubMed: Ustun Z et al., 2025 (PMID 37985661)

Bone Tissue Protection and Microstructure

In ovariectomized and orchidectomized rodent models, LGD-4033 has demonstrated dose-dependent improvements in bone mineral density and trabecular microstructure. AR agonism in osteoblasts promotes Runx2 expression, collagen deposition, and bone matrix mineralization, while concurrently modulating OPG/RANKL ratios to suppress osteoclast-mediated resorption — establishing LGD-4033 as a key research model for SARM-mediated osteoporosis intervention studies.

↗ PubMed: Hoffmann DB et al., 2023 (PMID 37592142)

Anti-Apoptotic and Anti-Oxidant Pathways

LGD-4033 AR agonism has been shown to activate anti-apoptotic signalling by upregulating Bcl-2 and downregulating caspase-3 and caspase-9 activation in muscle cell toxicity models. Concurrently, LGD-4033 reduces oxidative stress markers including malondialdehyde (MDA) and reactive oxygen species (ROS), while upregulating antioxidant enzymes including superoxide dismutase (SOD) — effects studied in cisplatin-induced myotoxicity research paradigms.

↗ PubMed: Ustun Z et al., 2025 (PMID 37985661)

HPG Axis Dose-Dependent Suppression

In a Phase I clinical pharmacokinetics study, LGD-4033 produced dose-dependent suppression of total testosterone, SHBG, FSH, and LH through hypothalamic-pituitary-gonadal axis negative feedback — effects that were fully reversible following compound discontinuation. This well-characterized HPG suppression profile makes LGD-4033 a reference compound for studying dose-dependent gonadotropin feedback kinetics and reversibility in androgen-dependent endocrine research models.

↗ PubMed: Basaria S et al., 2013 (PMID 24171373)

Traceability

Lot Verification Portal

Every PureRawz LGD-4033 vial carries a unique lot number linked to its own dual COA. MedChemExpress requires a form request. Behemothlabz has no portal. PureRawz gives you instant, public, lot-level access.

📄

HPLC Chromatogram

Full UV trace with peak identification for your exact LGD-4033 production lot.

🧫

LAL Endotoxin Report

Numerical EU/ml result and assay methodology for your specific lot — no form required.

🔬

Manufacturing Chain

Lot issuance date, USA manufacturing location, and third-party testing lab reference.

📋

IRB-Ready Documentation

COA formatted for institutional review board and IACUC protocol submissions.

📚

Publication Support

Lot-specific data ready for materials & methods sections of peer-reviewed journals.

🔒

Tamper-Evident Traceability

Unique lot numbers immutably linked — no shared or duplicated batch assignments.

Market Comparison

How PureRawz Compares

An objective comparison of data publicly available on each supplier's LGD-4033 product page as of April 2026.

Criteria	PureRawz	MedChemExpress	Behemothlabz (Capsule)
HPLC Purity Claim	≥99%	99.93% (stated)	Not stated on capsule page
HPLC COA Accessible	✓ Instant via /verify	✗ Form request required — not instant	COA images shown — no lot portal
LAL Endotoxin COA	✓ Per lot, public	✗ Not listed on product page	✗ Not listed
Unique Lot # Per Vial	✓ Yes	Batch Cat. No. system	✗ Not stated
Public Lot Verification Portal	✓ /verify	✗ No public portal	✗ No
USA Based / Manufactured	✓ USA	✗ China HQ (US warehouse available)	✓ USA
Shipping Speed	1 business day	1–2 days (USA WH) / variable global	24–48 hours processing
No Rx Required	✓ Yes	Research accounts — no patient sales	✓ Yes (age verification)
Trust Badges on Page	5 badges	Publication citations widget	COA links only
FAQ Section on Page	✓ 10 Q&As + schema	✗ No	✗ No
PubMed References on Page	✓ 6 linked	2–3 references listed	3 references (links, not inline)
FAQPage Schema Markup	✓ Full JSON-LD	✗ No	✗ No

Frequently Asked

LGD-4033 Research FAQ

Answers to the most common questions researchers ask before purchasing LGD-4033 (Ligandrol) from PureRawz.

Is LGD-4033 from PureRawz intended for human use?+

No. LGD-4033 (Ligandrol) from PureRawz is sold strictly for in vitro and in vivo laboratory research purposes only. It is not approved by the FDA for human consumption, veterinary use, or therapeutic application. All sales are restricted to qualified researchers and research institutions. Purchasers are solely responsible for compliance with all applicable institutional and legal regulations.

How does PureRawz LGD-4033 purity compare to MedChemExpress and Behemothlabz?+

MedChemExpress lists their LGD-4033 (Cat. HY-13981) at 99.93% purity but requires a contact form submission to receive the QC report — no instant public access exists. No LAL endotoxin data appears on their product page. Behemothlabz provides COA images on their capsule page but does not state a specific purity percentage on the product listing itself, and no LAL endotoxin certificate is provided. PureRawz guarantees ≥99% HPLC purity with a dual COA — both HPLC and LAL endotoxin — retrievable instantly by unique lot number at /verify with no form required.

What is a dual COA and why does it matter for LGD-4033 research?+

A dual COA combines HPLC purity verification with an independent LAL endotoxin test certificate. HPLC cannot detect bacterial lipopolysaccharides. Even nanogram-level LPS activates TLR4 → NF-κB signalling, triggering IL-6, TNF-α, caspase activation, and ROS production — completely confounding LGD-4033 anti-apoptotic, anabolic, or bone metabolism studies. Neither MedChemExpress nor Behemothlabz publish LAL endotoxin data on their LGD-4033 pages, leaving researchers unable to rule out endotoxin as a confounding variable.

What is the PureRawz lot verification system for LGD-4033?+

Every PureRawz LGD-4033 vial carries a unique lot number (e.g., PRZ-LGD4033-2025-0088) printed on the label. Researchers enter this number at officialpurerawz.us/verify to instantly retrieve the HPLC chromatogram, LAL endotoxin EU/ml result, manufacturing date, and third-party testing lab reference for that specific lot — with no form submission required. No competitor currently provides this level of real-time, public, per-lot dual COA access for LGD-4033.

How fast does PureRawz ship LGD-4033 and where does it ship from?+

PureRawz dispatches all USA domestic LGD-4033 orders within 1 business day. All product is manufactured and shipped from within the United States. MedChemExpress is China-headquartered with US warehouse stock subject to availability. Behemothlabz ships domestically with 24–48 hour processing time. PureRawz matches domestic dispatch speed while adding instant lot-verified dual COA access that no capsule or liquid competitor currently provides. All shipments include tracking information.

How should LGD-4033 be stored to maintain compound integrity?+

Store LGD-4033 as a crystalline solid at –20°C in a sealed, desiccated container protected from light and moisture for up to 3 years. Upon reconstitution into DMSO stock solutions (up to ~10 mg/ml), aliquot immediately into single-use volumes and store at –20°C for up to 1 month, or at –80°C for up to 6 months. Avoid repeated freeze-thaw cycles of reconstituted solutions. Degraded compound from improper storage can produce artefactual results in dose-response studies.

How do you reconstitute LGD-4033 for in vitro and in vivo studies?+

LGD-4033 is practically insoluble in water (<0.1 mg/ml) and requires organic solvents for stock preparation. Recommended protocol: dissolve in DMSO to ~10 mg/ml with sonication if needed, then dilute serially into aqueous cell culture medium ensuring final DMSO is ≤0.1% v/v to prevent vehicle cytotoxicity. For in vivo: use 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% saline vehicle to achieve ~0.5–1 mg/ml working concentrations. Always include a vehicle-matched control for every treatment group.

Does PureRawz offer LGD-4033 in different sizes or formats?+

PureRawz offers LGD-4033 (Ligandrol) in multiple research quantities to suit laboratory scale requirements. For institutional or bulk procurement exceeding standard catalog quantities, researchers can contact PureRawz directly. Custom lot documentation, specific endotoxin thresholds, and COA formats compatible with IRB or IBC review can be arranged for institutional purchasers. Bulk orders receive dedicated lot-specific dual COA and priority 1-business-day dispatch.

What is the legal and regulatory status of LGD-4033 in the USA?+

LGD-4033 (Ligandrol, VK5211) is an investigational compound that has completed Phase I and Phase II clinical trial stages but has not received FDA approval for any therapeutic use. As of this page's publication date, it is not listed as a scheduled controlled substance under the US Controlled Substances Act and is legal to purchase for legitimate laboratory research without a prescription in the USA. It is prohibited by WADA for use in competitive sport. Researchers must comply with all applicable institutional, federal, state, and local regulations.

Can I purchase LGD-4033 in bulk from PureRawz for institutional research?+

Yes. PureRawz accommodates bulk procurement for universities, contract research organizations (CROs), and institutional laboratories. Bulk orders receive dedicated per-lot dual COA documentation (HPLC + LAL endotoxin), priority 1-business-day dispatch, and volume pricing. Institutional purchase order and invoice options are available. Contact PureRawz via the website for a volume quote and custom documentation requirements.

Scientific Literature

PubMed-Linked References

This page cites peer-reviewed research available in the National Library of Medicine's PubMed database.

[1]
Basaria S, Collins L, Dillon EL, et al. The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87–95. PMID 24171373 ↗
[2]
Hoffmann DB, Komrakova M, Pflüger I, et al. Effects of Ligandrol as a Selective Androgen Receptor Modulator in a Rat Model for Osteoporosis. J Bone Miner Metab. 2023;41(6):741–751. PMID 37592142 ↗
[3]
Ustun Z, et al. Protective Effects of Ligandrol Against Cisplatin-Induced Mouse Muscle Cell Line Toxicity. Pharmaceutical Chemistry Journal. 2025. Anti-apoptotic and antioxidant pathway reference. PMID 37985661 ↗
[4]
Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy? Transl Androl Urol. 2020;9(S2):S135–S148. PMID 32257855 ↗
[5]
Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009;12(3):232–40. Foundational AR selectivity mechanism reference. PMID 19357508 ↗
[6]
Machek SB, Cardaci TD, Wilburn DT, Willoughby DS. Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of SARMs. Steroids. 2020;164:108753. PMID 30790397 ↗

RESEARCH USE ONLY DISCLAIMER: All products sold by PureRawz (officialpurerawz.us) are intended exclusively for in vitro and in vivo scientific research by trained laboratory personnel. LGD-4033 (Ligandrol, VK5211) is NOT approved by the Food and Drug Administration (FDA) for human use. It is NOT a dietary supplement, pharmaceutical drug, or therapeutic agent. It is NOT intended for human consumption, self-administration, or veterinary use. PureRawz makes no medical claims and all information on this page is provided for educational and research reference purposes only. Researchers are solely responsible for compliance with all applicable institutional, federal, state, and international regulations governing the purchase, handling, and use of research chemicals. By purchasing from PureRawz, the buyer confirms they are a qualified research professional and that the compound will be used only for legitimate scientific research purposes.