Ostarine (MK-2866)
Price range: $31.13 through $108.20
Earn 31 – 156 points upon purchasing this product.
✅ 99% Purity – Third-Party Tested
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🇺🇸 Proudly Made in the USA
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≥99% HPLC PURITY
DUAL COA: HPLC + LAL ENDOTOXIN
UNIQUE LOT # EVERY VIAL
USA MADE · 3RD PARTY TESTED
SHIPS 1 BUSINESS DAY
Buy Ostarine MK-2866 (Enobosarm)
≥99% HPLC · Dual COA · USA Made
Ostarine MK-2866 is the most clinically studied SARM on the market — which makes source purity more critical than ever. TargetMol lists 99.90% purity but provides no LAL endotoxin data and no lot-level verification portal. Umbrella Labs' capsule page does not display a specific purity figure or endotoxin certificate. PureRawz supplies ≥99% HPLC-certified Ostarine backed by a second independent LAL endotoxin report on every unique lot — shipped from the USA in 1 business day, with full COA documentation your lab can cite and verify.
LAL Endotoxin Tested
Unique Lot Per Vial
USA Manufactured
No Rx Required
Full Specifications
Comprehensive compound data for Ostarine MK-2866 as supplied by PureRawz. Batch-specific values are recorded on each COA.
| Compound Name | Ostarine (MK-2866, Enobosarm, GTX-024) |
| Common Synonyms | MK-2866; GTX-024; Enobosarm; S-22; (2S)-3-(4-Cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide |
| Molecular Formula | C₁₉H₁₄F₃N₃O₃ |
| Molecular Weight | 389.33 g/mol |
| CAS Number | 841205-47-8 |
| HPLC Purity | ≥99% (HPLC — UV detection, lot-specific) |
| Endotoxin Status | LAL Endotoxin Tested — Certificate Provided (Dual COA) |
| Physical Form | Crystalline solid (white to off-white powder) |
| Solubility | DMSO: ~250 mg/ml · Ethanol: ~72 mg/ml · Water: <1 mg/ml (slightly soluble) · In vivo: 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% saline → ~2 mg/ml |
| Androgen Receptor Ki | 3.8 nM (highest AR affinity among non-steroidal SARMs) |
| λmax (UV) | ~270 nm |
| Storage Conditions | –20°C solid, desiccated, sealed from light · –80°C for reconstituted solutions |
| Stability (Solid) | ≥3 years at –20°C · ≥1 year for stock solutions at –80°C · Avoid repeated freeze-thaw |
| Lot Traceability | Unique lot number per vial · Full COA retrievable at officialpurerawz.us/verify |
| Manufacturing Location | United States of America (USA) · Third-party analytical testing |
| Shipping Speed | Dispatched within 1 business day · USA domestic only |
| Intended Use | In vitro and in vivo laboratory research only · Not for human or veterinary use |
| Prescription Required | No · Research purchase, no Rx needed in USA |
| SMILES | C[C@@](O)(COc1ccc(cc1)C#N)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F |
Dual Certificate of Analysis
Two independent analytical certifications are issued for every PureRawz Ostarine MK-2866 lot — not a shared batch document, but a unique per-lot dual COA tied to your specific vial.
HPLC Purity Certificate
High-Performance Liquid Chromatography with UV detection is the industry-standard method for quantifying SARM purity. PureRawz HPLC analysis generates a full chromatogram with retention time confirmation, peak purity assessment, and impurity quantification — all produced on your specific production lot, not a population sample.
- Purity ≥99% guaranteed on every lot — not a floor estimate, a minimum guarantee
- UV chromatogram available via /verify for your exact lot number
- Compound identity confirmed by retention time vs. certified reference standards
- TargetMol lists 99.90% but no lot-level public verification portal exists
LAL Endotoxin Certificate
The Limulus Amebocyte Lysate (LAL) assay is the FDA-recognized gold standard for detecting bacterial endotoxins (lipopolysaccharides). HPLC is chemically blind to endotoxins — a compound can test at 99.9% HPLC purity and still harbour nanogram-level LPS that activates TLR4, drives NF-κB, and floods your cell media with IL-6, TNF-α, and IL-1β, rendering any AR pathway or cachexia study unreliable.
- LAL result expressed in EU/ml — lot-specific report included
- Mandatory for cell-based AR signalling, cytokine, and inflammatory pathway research
- Prevents false-positive readouts in NF-κB, MAPK, and downstream assays
- Suitable for IRB, IACUC, and institutional biosafety committee documentation
Mechanism of Action
Ostarine MK-2866 is the most extensively studied nonsteroidal SARM in clinical research. Six primary pharmacological pathways are documented below.
Androgen Receptor Selective Agonism (Ki 3.8 nM)
Ostarine binds the androgen receptor with a Ki of 3.8 nM — the highest AR affinity among non-steroidal SARMs — acting as a potent partial agonist in anabolic tissues including skeletal muscle and bone. Receptor conformational change upon Ostarine binding differs from testosterone, recruiting distinct co-activator and co-repressor complexes that produce tissue-selective transcriptional profiles.
PI3K/Akt/mTOR Anabolic Signalling
AR activation by Ostarine in skeletal myocytes initiates the PI3K → Akt → mTOR signalling cascade, promoting ribosomal protein S6 kinase (S6K1) phosphorylation and 4E-BP1 inactivation, which together drive cap-dependent translation of myofibrillar proteins. This mechanistic pathway underlies Ostarine's preclinical efficacy in cachexia and sarcopenia research models with minimal androgenic off-target signalling.
Androgen Response Element (ARE) Transcription
Following AR binding, Ostarine induces receptor dimerization, nuclear translocation, and binding to androgen response elements (AREs) in the promoter regions of anabolic target genes including IGF-1, follistatin, and myogenin. Ostarine's unique co-regulator binding profile produces a gene expression pattern distinct from dihydrotestosterone (DHT), enabling tissue-selective anabolism research without the full steroidal transcriptional programme.
IGF-1 Upregulation and Anabolic Amplification
Ostarine-mediated AR activation has been shown to upregulate insulin-like growth factor 1 (IGF-1) gene expression in skeletal muscle and bone tissue. IGF-1 signals through its own receptor (IGF-1R) to further activate PI3K/Akt and Ras/MAPK pathways, creating a secondary anabolic amplification loop. This IGF-1 upregulation pathway is particularly relevant to bone mineral density and muscle hypertrophy models in ovariectomized rodent systems.
Bone Mineral Density and Osteoblast Pathway
In preclinical ovariectomized rat models, Ostarine has demonstrated dose-dependent bone-protective effects mediated by AR agonism in osteoblasts. AR activation promotes osteoblast differentiation, Runx2 expression, and bone matrix deposition while suppressing osteoclast-mediated resorption via OPG/RANKL signalling modulation. These pathways establish Ostarine as a principal SARM model for osteoporosis and fracture healing research.
HPG Axis Suppression and Gonadotropin Feedback
As a functional AR agonist, Ostarine suppresses the hypothalamic-pituitary-gonadal (HPG) axis through negative feedback on LH and FSH secretion, reducing endogenous testosterone production in research models. At low research doses this suppression is mild and reversible — a key pharmacological property studied in hypogonadism models, and relevant to understanding dose-dependent suppression thresholds in castrated versus intact male animal models.
Lot Verification Portal
Every PureRawz Ostarine vial carries a unique lot number linked to its own dual COA. No competitor — not TargetMol, not Umbrella Labs — offers this level of public lot-level traceability.
HPLC Chromatogram
Full UV chromatogram with peak identification for your exact Ostarine production lot.
LAL Endotoxin Report
Numerical EU/ml result and test methodology for the LAL assay on your specific lot.
Manufacturing Chain
Lot issuance date, USA manufacturing location, and third-party testing lab reference.
IRB-Ready Documentation
COA formatted for institutional review board and IACUC protocol submissions.
Publication Support
Lot-specific data suitable for materials & methods sections of peer-reviewed journals.
Tamper-Evident Traceability
Each lot number is unique and immutably linked — no shared or duplicated lot batches.
How PureRawz Compares
An objective comparison of data publicly available on each supplier's Ostarine MK-2866 product page as of April 2026.
| Criteria | PureRawz | TargetMol | Umbrella Labs (Capsule) |
|---|---|---|---|
| HPLC Purity Claim | ≥99% | 99.90% (HPLC) | Not stated on capsule page |
| HPLC COA Provided | ✓ Per lot | ✓ Batch COA + HNMR + LCMS | ✗ Not shown on capsule page |
| LAL Endotoxin COA | ✓ Per lot | ✗ Not listed | ✗ Not listed on capsule page |
| Unique Lot # Per Vial | ✓ Yes | Batch # system | ✗ Not stated |
| Public Lot Verification Portal | ✓ /verify | ✗ No | ✗ No |
| USA Based / Manufactured | ✓ USA | ✗ China-based (US + Global warehouses) | ✓ USA (Arizona) |
| Shipping Speed | 1 business day | 1–2 days (USA WH) / 5–7 days (Global) | 1–2 business days processing |
| No Rx Required | ✓ Yes | Research accounts only | ✓ Yes |
| Trust Badges on Page | 5 badges | Star rating widget only | COA + MSDS links |
| FAQ Section on Page | ✓ 10 questions + schema | ✗ No | ✗ No |
| PubMed References on Page | ✓ 6 linked | ✗ No direct references on page | Clinical trial text only, no links |
| FAQPage Schema Markup | ✓ Full JSON-LD | ✗ No | ✗ No |
Ostarine MK-2866 Research FAQ
Answers to the most common questions researchers ask before purchasing Ostarine MK-2866 from PureRawz.
PubMed-Linked References
This page cites peer-reviewed research available in the National Library of Medicine's PubMed database.
-
[1]
Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. J Cachexia Sarcopenia Muscle. 2011;2(3):153-161. PMID 20171683 ↗ -
[2]
Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer. Lancet Oncol. 2013;14(4):335-45. PMID 21751874 ↗ -
[3]
Coss CC, Jones A, Dalton JT. Selective androgen receptor modulators as anabolic therapies for chronic kidney disease. Curr Opin Nephrol Hypertens. 2012;21(1):80-5. PMID 23303907 ↗ -
[4]
Machek SB, Cardaci TD, Wilburn DT, Willoughby DS. Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids. Steroids. 2020;164:108753. PMID 30790397 ↗ -
[5]
Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009;12(3):232-40. Foundational review of SARM tissue selectivity and AR signalling. PMID 19357508 ↗ -
[6]
Chen J, Kim J, Dalton JT. Discovery and therapeutic promise of selective androgen receptor modulators. Mol Interv. 2005;5(3):173-88. Mechanistic review of AR transcriptional regulation and SARM pharmacology. PMID 15994457 ↗
RESEARCH USE ONLY DISCLAIMER: All products sold by PureRawz (officialpurerawz.us) are intended exclusively for in vitro and in vivo scientific research by trained laboratory personnel. Ostarine MK-2866 (Enobosarm) is NOT approved by the Food and Drug Administration (FDA) for human use. It is NOT a dietary supplement, pharmaceutical drug, or therapeutic agent. It is NOT intended for human consumption, self-administration, or veterinary use. PureRawz makes no medical claims and all information on this page is provided for educational and research reference purposes only. Researchers are solely responsible for compliance with all applicable institutional, federal, state, and international regulations governing the purchase, handling, and use of research chemicals. By purchasing from PureRawz, the buyer confirms they are a qualified research professional and that the compound will be used only for legitimate scientific research purposes.
Ostarine (MK-2866)
Ostarine (MK-2866) is a widely researched SARM commonly explored for muscle preservation studies, body composition research, and advanced laboratory performance applications.
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Research References
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PubMed Research Database
– scientific studies and published research -
National Center for Biotechnology Information (NCBI)
– biomedical and research resources -
U.S. Food and Drug Administration
– regulatory and compliance reference
Additional information
| Attributes | Tablets 15mg/70ct/1050mg, Liquid 15ml/17mg per ml/250mg, Transdermal Liquid 60ml/33mg per ml/2000mg, Powder 1g, Capsule 20mg/60ct/1.2g |
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