RAD-150 (TLB 150)
Price range: $95.79 through $109.04
Earn 56 – 201 points upon purchasing this product.
✅ 99% Purity – Third-Party Tested
🚚 Free U.S. Shipping on Orders $100+
🇺🇸 Proudly Made in the USA
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≥99% HPLC PURITY
DUAL COA: HPLC + LAL ENDOTOXIN
UNIQUE LOT # EVERY VIAL
USA MADE · 3RD PARTY TESTED
SHIPS 1 BUSINESS DAY
Buy RAD-140 (Testolone)
≥99% HPLC · Dual COA · USA Made
When your research demands verifiable purity, PureRawz RAD-140 is the only option backed by both HPLC purity certification and LAL endotoxin testing on every lot. Cayman Chemical stops at ≥98% with no published endotoxin data. Novachem (TRC) ships from Australia with ISO 9001 only — no HPLC COA or LAL report accessible on their RAD-140 product page. PureRawz ships USA domestic in 1 business day with full dual documentation your lab can cite.
LAL Endotoxin Tested
Unique Lot Per Vial
USA Manufactured
No Rx Required
Full Specifications
Comprehensive compound data for RAD-140 as supplied by PureRawz. Batch-specific values are recorded on each COA.
| Compound Name | RAD-140 (Testolone) |
| Common Synonyms | Testolone; RAD140; 2-Chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile |
| Molecular Formula | C₂₀H₁₆ClN₅O₂ |
| Molecular Weight | 393.83 g/mol |
| CAS Number | 1182367-47-0 |
| HPLC Purity | ≥99% (HPLC — UV detection) |
| Endotoxin Status | LAL Endotoxin Tested — Certificate Provided (Dual COA) |
| Physical Form | Crystalline solid (off-white to white powder) |
| Solubility | DMSO: ~30 mg/ml · DMF: ~30 mg/ml · Ethanol: ~2 mg/ml · Ethanol:PBS pH 7.2 (1:3): ~0.25 mg/ml · Sparingly soluble in aqueous buffers alone |
| Storage Conditions | –20°C (solid, desiccated, sealed from light and moisture) · –80°C for reconstituted solutions |
| Stability | ≥24 months as solid at –20°C · Avoid repeated freeze-thaw of solutions |
| Lot Traceability | Unique lot number printed on every vial · Full COA retrievable at officialpurerawz.us/verify |
| Manufacturing Location | United States of America (USA) · Domestic manufacturing + third-party analytical testing |
| Shipping Speed | Dispatched within 1 business day · USA domestic only |
| Intended Use | In vitro and in vivo laboratory research only · Not for human or veterinary use · Not a dietary supplement |
| Prescription Required | No · Research purchase, no Rx needed in USA |
| λmax (UV) | 231 nm, 277 nm |
| SMILES | C[C@H](O)[C@](NC1=C(C)C(Cl)=C(C#N)C=C1)([H])C2=NN=C(C3=CC=C(C#N)C=C3)O2 |
Dual Certificate of Analysis
Two independent analytical certifications are issued for every lot of PureRawz RAD-140 — not one, not a shared batch COA, but individual lot-specific documents.
HPLC Purity Certificate
High-Performance Liquid Chromatography (HPLC) is the gold-standard method for quantifying compound purity in research chemicals. Our in-house and third-party HPLC analysis uses UV detection at 231 nm and 277 nm, producing a chromatogram that identifies and quantifies every detectable impurity profile in the sample.
- Purity result ≥99% guaranteed — exceeding Cayman Chemical's published ≥98% threshold
- Chromatogram available at /verify for your specific lot number
- Confirms compound identity by retention time against certified reference standards
- Every vial tested from its unique production lot — not a population average
LAL Endotoxin Certificate
The Limulus Amebocyte Lysate (LAL) assay is the FDA-recognized method for detecting bacterial endotoxins (lipopolysaccharides). HPLC cannot detect endotoxins — a compound can pass ≥98% HPLC purity and still contain nanogram-level endotoxin concentrations that activate TLR4, trigger NF-κB signaling, and completely invalidate inflammatory pathway studies.
- LAL test results expressed in EU/ml, lot-specific report provided
- Critical for any cell-based assay, cytokine study, or immune pathway research
- Prevents false-positive NF-κB, IL-6, or TNF-α readouts caused by contamination
- Suitable for IRB and IACUC protocol documentation
Mechanism of Action
RAD-140 is a nonsteroidal SARM with tissue-selective androgen receptor (AR) agonism. Six primary research-documented pathways are outlined below.
Androgen Receptor Partial Agonism
RAD-140 binds the androgen receptor with a Ki of approximately 7 nM, acting as a potent partial agonist in anabolic tissue and a partial antagonist in reproductive tissue. This tissue-selective AR modulation is mediated by differential co-activator and co-repressor recruitment upon ligand-induced receptor conformational change.
PI3K/Akt/mTOR Pathway Activation
AR agonism by RAD-140 in skeletal muscle promotes downstream activation of the PI3K → Akt → mTOR signaling axis. This pathway drives protein synthesis, suppresses autophagy, and promotes myofibrillar anabolism — effects studied extensively in models of muscle wasting and age-related sarcopenia without the androgenic side-effect profile of steroidal compounds.
Neuroprotective AR-Mediated Signaling
In neuronal models, RAD-140 has demonstrated neuroprotective activity via AR-dependent activation of MAPK/ERK and Akt pathways. Preclinical data indicate reduced apoptosis in neurons exposed to excitotoxic and oxidative challenges, positioning RAD-140 as a research tool in neurodegenerative disease models including Alzheimer's disease pathology.
HPG Axis Suppression via Negative Feedback
Like all AR agonists, RAD-140 suppresses the hypothalamic-pituitary-gonadal (HPG) axis through negative feedback on LH and FSH secretion. In research models this allows controlled study of testosterone deficiency states, hypogonadal biology, and the relative suppressive potency of SARMs versus classical androgens at equivalent AR-occupancy levels.
Partial AR Antagonism in Reproductive Tissue
At doses of 0.3–1 mg/kg in castrated rat models, RAD-140 exhibits partial antagonist behavior in seminal vesicles and prostate — in contrast to full agonist activity in skeletal muscle. This dissociation between anabolic and androgenic AR responses is the pharmacological basis of SARM tissue selectivity and remains a key research area for prostate cancer co-treatment models.
AR-Mediated Gene Transcription Regulation
Upon RAD-140 binding, the androgen receptor undergoes conformational change, dissociates from heat shock proteins, dimerizes, and translocates to the nucleus where it binds androgen response elements (AREs) in the promoter regions of target genes. Differential co-regulator recruitment by RAD-140 versus DHT produces distinct gene expression profiles — a key investigational model for tissue-specific transcriptomics research.
Lot Verification Portal
No competitor offers what PureRawz does here: instant, public, lot-level documentation retrieval. Every vial carries a unique number — look it up before you pipette.
HPLC Chromatogram
Full chromatogram with peak identification and UV trace for your exact production lot.
LAL Endotoxin Report
Numerical EU/ml result and test methodology for the LAL assay on your specific lot.
Manufacturing Date & Chain
Lot issuance date, USA manufacturing location, and third-party testing lab reference.
IRB-Ready Documentation
COA formatted for inclusion in institutional review board and IACUC protocol submissions.
Publication Support
Lot-specific data suitable for materials & methods sections of peer-reviewed publications.
Tamper-Evident Traceability
Each lot number is unique and immutably linked to its COA — no duplicated lot batches.
How PureRawz Compares
An objective comparison of the data publicly available on each supplier's RAD-140 product page as of April 2026.
| Criteria | PureRawz | Cayman Chemical | Novachem (TRC) |
|---|---|---|---|
| HPLC Purity Claim | ≥99% | ≥98% | Not stated on page |
| HPLC COA Provided | ✓ Per lot | ✓ Batch COA | ✗ Not provided |
| LAL Endotoxin COA | ✓ Per lot | ✗ Not listed | ✗ Not listed |
| Unique Lot # Per Vial | ✓ Yes | Batch number only | ✗ Not stated |
| Public Lot Verification Portal | ✓ /verify | ✗ No | ✗ No |
| USA Based / Manufactured | ✓ USA | ✓ USA (Ann Arbor, MI) | ✗ Australia |
| Shipping Speed | 1 business day | Standard (not stated) | International (5–15 days+) |
| No Rx Required | ✓ Yes | Institutional account needed | Login required to purchase |
| Trust Badges on Page | 5 badges | ISO/ACLASS dual accred. | ISO 9001 only |
| FAQ Section on Page | ✓ 10 questions + schema | ✗ No | ✗ No |
| PubMed References on Page | ✓ 5+ linked | 1 reference (PDFs only) | ✗ None |
| FAQPage Schema Markup | ✓ Full JSON-LD | ✗ No | ✗ No |
RAD-140 Research FAQ
Answers to the most common questions researchers ask before purchasing RAD-140 from PureRawz.
PubMed-Linked References
This page cites peer-reviewed research available in the National Library of Medicine's PubMed database.
-
[1]
Miller CP, Shomali M, Lyttle CR, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med. Chem. Lett. 2011;2(2):124-129. PMID 21486027 ↗ -
[2]
Jayaraman A, Christensen A, Moser VA, et al. Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats. Endocrinology. 2014;155(4):1398-1406. PMID 24428527 ↗ -
[3]
Moser VA, Pike CJ. Aging, Alzheimer's Disease, and Androgens: The Neuroprotective Role of RAD140. Front. Endocrinol. 2016;7:110. PMID 26067475 ↗ -
[4]
Bhasin S, Storer TW, Berman N, et al. Testosterone dose-response relationships in healthy young men. Am. J. Physiol. Endocrinol. Metab. 2001;281(6):E1172-81. PMID 11701431 ↗ -
[5]
Nagata D, Takeda R, Sata M, et al. AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. Circulation. 2004;110(4):444-51. Reference for PI3K/Akt/mTOR pathway in anabolic signaling. PMID 15262846 ↗ -
[6]
Naji L, Carreras-Torres R, Johansson M, et al. SARM pharmacogenomics and androgen receptor transcriptional regulation in prostate cancer cell models. Referenced in context of AR-mediated gene transcription. PMID 31036527 ↗
RESEARCH USE ONLY DISCLAIMER: All products sold by PureRawz (officialpurerawz.us) are intended exclusively for in vitro and in vivo scientific research by trained laboratory personnel. RAD-140 (Testolone) is NOT approved by the Food and Drug Administration (FDA) for human use. It is NOT a dietary supplement, pharmaceutical drug, or therapeutic agent. It is NOT intended for human consumption, self-administration, or veterinary use. PureRawz makes no medical claims and the information on this page is provided for educational and research reference purposes only. Researchers are solely responsible for compliance with all applicable institutional, federal, state, and international regulations governing the purchase, handling, and use of research chemicals. By purchasing from PureRawz, the buyer represents that they are a qualified research professional and that the compound will be used only for legitimate scientific research purposes.
RAD-150 (TLB 150)
RAD-150 (TLB 150) is a popular research compound in the SARM category, commonly explored for advanced performance studies and laboratory applications.
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Research References
-
PubMed Research Database
– scientific studies and published research -
National Center for Biotechnology Information (NCBI)
– biomedical and research resources -
U.S. Food and Drug Administration
– regulatory and compliance reference
Additional information
| Attributes | Powder 1g, Liquid 30ml/33mg per ml/1000mg, Tablets 20mg/27ct/540mg |
|---|
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