What is Semax used for in research?

Semax is studied in laboratory settings for its interactions with neurotrophic signalling (BDNF/NGF), neuroprotection models, gene expression in hippocampal and cortical tissue, and dopaminergic/serotonergic pathway research. All uses are strictly in-vitro or preclinical.

What purity is PureRawz Semax?

PureRawz Semax is ≥99% pure as verified by third-party HPLC analysis. Each lot ships with two Certificates of Analysis: one for chemical purity (HPLC) and one for endotoxin safety (LAL assay).

What is a dual COA and why does it matter?

A dual COA means PureRawz provides two separate Certificates of Analysis per lot: (1) an HPLC purity report confirming ≥99% chemical identity, and (2) a LAL endotoxin assay confirming bacterial endotoxin levels. HPLC alone cannot detect endotoxins, which can corrupt cell-based assay results at sub-nanogram concentrations.

Is Semax a controlled substance in the USA?

As of April 2026, Semax is not scheduled under the US Controlled Substances Act and is not FDA-approved for any medical use. It is sold strictly as a research reagent for in-vitro laboratory use.

How should I store Semax in my laboratory?

Store lyophilised Semax at −20°C in a desiccated, dark environment. Once reconstituted, use within 7 days at 2–8°C or aliquot and freeze at −20°C. Avoid repeated freeze-thaw cycles.

What solvents can I use to reconstitute Semax?

Semax dissolves in sterile water, PBS, or dilute acetic acid (0.1–1%). Recommended starting concentration ≥100 µg/mL.

What is the molecular weight and formula of Semax?

Semax (CAS 80714-61-0) has the sequence Met-Glu-His-Phe-Pro-Gly-Pro, molecular formula C₃₇H₅₁N₉O₁₀S, and a molecular weight of 813.92 g/mol.

What makes PureRawz different from competitors for Semax?

PureRawz is the only major domestic supplier to provide a dual COA (HPLC purity + LAL endotoxin), unique lot numbers traceable via our online verification portal, and 1-business-day domestic shipping from a USA facility.

Can I verify my Semax lot number independently?

Yes. Enter the lot number printed on your vial label at officialpurerawz.us/verify to retrieve both COA documents, the third-party lab name, and the testing date for your specific batch.

N-Acetyl Semax Amidate

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Buy Semax | ≥99% Pure | Dual COA | PureRawz USA

⚠ RESEARCH USE ONLY: All PureRawz products are strictly for in-vitro laboratory research. Not for human or animal consumption. Not FDA-approved. For use by qualified researchers only.
Full disclaimer ↓

≥99% Purity — HPLC Verified

Dual COA — HPLC + LAL Endotoxin

Unique Lot Numbers — Full Traceability

USA Manufactured & Third-Party Tested

Ships USA in 1 Business Day

✓ HPLC COA

✓ LAL COA

[Replace with product photo]

Lot: SX-2025-0941
QC: 2025-09-14
≥99.2% HPLC

Research Peptide · ACTH(4-7)PGP Analog

Buy Semax —
≥99% Purity + Dual COA

When you buy Semax from PureRawz, every vial arrives with two independent Certificates of Analysis — HPLC purity verification and an LAL endotoxin assay — traceable to a unique batch lot number. USA-manufactured, third-party tested, ships in 1 business day. No prescription required.

≥99% HPLC Purity
LAL Endotoxin Tested
Unique Lot Number
USA Manufactured
Ships in 1 Business Day

$[PRICE]
per vial · free shipping $[THRESHOLD]+

Add to Cart

View Both COAs

In-stock orders ship same business day — USA domestic only

Technical Data

Full Product Specifications

All data is verifiable via the lot-specific COA documents included with every order.

Compound Name	Semax (ACTH 4-7 PGP)
Synonyms	ACTH(4-10)PGP, Pro-Gly-Pro-ACTH, HY-P1146
Amino Acid Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula	C₃₇H₅₁N₉O₁₀S
Molecular Weight	813.92 g/mol
CAS Number	80714-61-0
Purity (HPLC)	≥99% — third-party verified per lot
Endotoxin (LAL)	Tested — COA included per lot
Physical Form	Lyophilised (freeze-dried) white powder
Solubility	Sterile water, PBS, or dilute acetic acid (0.1–1%)
Storage — Lyophilised	−20 °C, desiccated, protected from light
Storage — Reconstituted	2–8 °C short-term (≤7 d); −20 °C long-term
Stability	12–24 months lyophilised at −20 °C
Lot Traceability	Unique lot number — every vial, every batch
Manufacturing	USA (domestic synthesis and lyophilisation)
Testing	Independent third-party laboratory
Shipping	1 business day · USA domestic only
Intended Use	In-vitro laboratory research only

Quality Assurance

Why PureRawz Provides a Dual COA — And Why It Matters

Most peptide suppliers stop at HPLC purity. PureRawz issues two separate, lot-specific Certificates of Analysis for every batch of Semax. Here's the science behind why both are essential.

HPLC Purity Certificate

High-Performance Liquid Chromatography separates and quantifies every molecular species in the sample. Our Semax consistently measures ≥99% purity at lot release. The full chromatogram with peak integration is available in the COA PDF, confirming chemical identity and ruling out synthesis by-products or oxidation impurities. This is the industry-standard method — and where most suppliers stop.

≥99% purity confirmed per lot

LAL Endotoxin Assay Certificate

The Limulus Amebocyte Lysate (LAL) assay is the pharmacopoeial gold standard for detecting bacterial lipopolysaccharides (LPS). HPLC cannot detect endotoxins — LPS are large heteropolymers that don't resolve as chromatographic peaks. Even sub-nanogram LPS contamination activates TLR4 on macrophages, invalidating cytokine assays, cell-viability studies, and inflammatory pathway experiments. Neither of our two main competitors provides this test.

LAL endotoxin tested — per lot

Both COA documents are lot-number-specific and available for download from the product page.

Research Background

What Is Semax?

Semax is a synthetic heptapeptide with the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro, structurally derived from the 4th through 7th residues of adrenocorticotropic hormone (ACTH), extended at the C-terminus with a Pro-Gly-Pro (PGP) tripeptide motif. Semax was originally developed by the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has accumulated a substantial body of peer-reviewed preclinical literature spanning neurotrophic signalling, cerebral ischaemia models, and gene expression profiling.

Unlike native ACTH, Semax does not stimulate corticosteroid secretion from the adrenal cortex. The PGP C-terminal extension is considered by researchers to enhance the compound's lipophilicity, potentially supporting passive diffusion characteristics relevant to blood–brain barrier (BBB) permeability studies. Lipid raft-mediated endocytosis and receptor-mediated transcytosis at BBB tight junctions are two proposed mechanisms examined in the literature.

The acetylated variant — N-Acetyl Semax — adds an acetyl group to the N-terminal methionine. In preclinical pharmacokinetics modelling, acetylation is associated with reduced affinity for competing metal ions at the N-terminus and improved resistance to enzymatic degradation, potentially extending measurable half-life in biological matrices [1].

In published literature, Semax has been examined in preclinical contexts relating to BDNF and NGF upregulation, cerebral ischaemia models, serotonergic and dopaminergic pathway modulation, hippocampal and cortical gene expression profiling, and default mode network fMRI imaging. All findings cited here arise from in-vitro or animal-model studies only.

Mechanistic Science

Mechanism of Action — Six Research Pathways

Peer-reviewed preclinical literature has characterised at least six distinct molecular pathways. All findings are from in-vitro or animal studies only.

BDNF & NGF Upregulation

Transcriptomic studies in rodent models document time-dependent upregulation of BDNF and NGF gene expression in the hippocampus and frontal cortex following Semax exposure, with peak changes observed within 20 minutes of administration. BDNF signalling through TrkB receptors is the most-studied downstream target.

Agapova et al., 2008 [5]; Dolotov et al., Brain Res Bull 2011

Enkephalin Degradation Inhibition

Semax has been reported to inhibit dipeptidyl peptidase IV and related serine proteases implicated in enkephalin catabolism. Elevated enkephalin availability in preclinical models may modulate opioidergic, dopaminergic, and serotonergic pathway crosstalk — producing measurable changes in neurotransmitter metabolite levels.

Kost et al., Bioorg Khim 2001 [9]

24-Gene Vascular Expression Profile

Whole-transcriptome analyses in rodent focal ischaemia models identified Semax-associated changes across 24 genes regulating vascular biology — including smooth-muscle cell migration, erythropoiesis, and angiogenesis-related transcription factors in brain and spinal cord tissue.

Medvedeva et al., BMC Genomics 2014 [1]

Serotonergic System Modulation

Rodent studies measuring 5-HIAA (a primary serotonin metabolite) found progressive increases up to 180% over four hours following Semax exposure. Co-administration with D-amphetamine produced additive elevations in 5-HIAA, indicating monoamine pathway interaction beyond a simple direct receptor effect.

Eremin et al., Neurochem Res 2005 [8]

Default Mode Network Modulation

Functional MRI research reported Semax-associated changes in default mode network (DMN) connectivity — the resting-state brain system involved in social cognition, self-referential processing, and environmental monitoring. DMN disruption is observed in multiple neurodegenerative research models.

Lebedeva et al., Bull Exp Biol Med 2018 [3]

Neuroimmune & Microglial Signalling

Post-ischaemia transcriptomics identified Semax-associated effects on microglial activation, leukocyte pathway genes, and dendritic cell populations at 3 h and 24 h time points. Immunoglobulin and chemokine gene clusters were among the most significantly modulated.

Medvedeva et al., BMC Genomics 2014 [1]

Unique to PureRawz

Batch Traceability — Our Public Lot Verification Portal

Neither Peptide Sciences nor Biotech Peptides offers public batch-level verification. PureRawz does — because researchers shouldn't have to take our word for it.

Every vial is traceable to a specific, independently tested batch.

Our lot numbering system encodes the compound code, synthesis batch number, and QC release date. Every lot is indexed in our public verification portal — enter the lot number printed on your vial at officialpurerawz.us/verify and retrieve:

The HPLC purity COA PDF for your exact batch
The LAL endotoxin COA PDF for your exact batch
The name of the independent third-party testing laboratory
The QC release date and synthesis batch ID
Documentation suitable for IRB submissions and publication methodology sections

Sample Lot Number

SX-2025-0941

Compound: Semax
Batch: #941 · QC Released
Purity: ≥99.2% HPLC

Verify at /verify →

Supplier Comparison

PureRawz vs. Competitors — Semax Side-by-Side

Based on publicly available supplier information as of April 2026.

Feature	PureRawz ✦	Peptide Sciences	Biotech Peptides
Purity Standard	≥99% HPLC	99% HPLC	99% HPLC
HPLC Purity COA	✔ Per lot	✔ Per lot	✔ Per lot
LAL Endotoxin COA	✔ Per lot — full assay	✗ Not provided	✗ Not provided
Unique Lot Number Per Vial	✔ Every vial	Partial	✗ Not mentioned
Public Lot Verification Portal	✔ officialpurerawz.us/verify	✗	✗
USA Manufactured	✔	✔	✔
Ships in 1 Business Day (USA)	✔	Not stated	✔ Same-day by 12 PST
No Prescription Required	✔	✔	✔
Trust Badge Strip on Page	✔ 5 badges	3 badges	✗ None
FAQ Section (Schema Rich Results)	✔ 10 Q&As	✗	✗
PubMed-Linked References	✔ 9 cited	✔ ~8 cited	✔ 9 cited
Site Operational (Apr 2026)	✔ Active	✗ Reports of shutdown	✔ Active

✦ PureRawz. Data from publicly available pages, April 2026. Subject to change.

Related Research Compounds

Researchers Studying Semax Also Explore

Frequently Asked Questions

Semax Research FAQ

For research and educational purposes only. Nothing here constitutes medical advice.

What is Semax and what is it used for in research?
+

Semax (ACTH 4-7 PGP; CAS 80714-61-0) is a synthetic heptapeptide analog of adrenocorticotropic hormone fragment 4–10 with a C-terminal Pro-Gly-Pro extension. In laboratory settings it has been studied for interactions with neurotrophic signalling (BDNF/NGF/TrkB axis), neuroprotection in cerebral ischaemia models, serotonergic and dopaminergic pathway modulation, gene expression profiling in hippocampal and cortical tissue, and default mode network imaging. All research use is strictly in-vitro or preclinical.

What purity does PureRawz Semax have and how is it verified?
+

PureRawz Semax is manufactured to ≥99% purity as measured by HPLC on a per-lot basis by an independent third-party laboratory. The full chromatogram with peak integration is included in the HPLC COA PDF provided with every order. Lot-level purity data is also accessible via our public verification portal at officialpurerawz.us/verify.

What is a dual COA and why does PureRawz provide one when competitors don't?
+

A dual COA means PureRawz provides two independent, lot-specific Certificates of Analysis: (1) an HPLC purity report confirming ≥99% chemical identity, and (2) an LAL endotoxin assay confirming bacterial lipopolysaccharide (LPS) levels fall within acceptable research limits. HPLC cannot detect endotoxins because LPS molecules are large heteropolymers that don't resolve as chromatographic peaks. Even trace-level (sub-nanogram) endotoxin contamination can activate TLR4 on macrophages, confounding cytokine assays, cell-viability studies, and any inflammation-related experimental readout. As of April 2026, neither Peptide Sciences nor Biotech Peptides provides a LAL endotoxin COA with their Semax.

How does PureRawz's lot number system work?
+

Every PureRawz vial carries a unique lot number encoding the compound identifier, synthesis batch number, and QC release date. Entering that lot number at officialpurerawz.us/verify returns both the HPLC purity COA and the LAL endotoxin COA for that specific batch, along with the testing laboratory's identity and QC release date. This documentation is useful for IRB submissions, publication methodology sections, and multi-lab reproducibility studies requiring reagent provenance records.

How quickly does PureRawz ship Semax, and where do you ship?
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All in-stock PureRawz orders ship within 1 US business day from our domestic USA facility. Tracking information is provided automatically upon dispatch. We ship exclusively within the United States. No prescription or institutional affiliation is required to purchase Semax from PureRawz.

How should I store lyophilised Semax in my laboratory?
+

Store lyophilised Semax at −20 °C or below, in a sealed desiccated container, away from light and moisture. Under these conditions, lyophilised peptides are typically stable for 12–24 months. Once reconstituted, store the solution at 2–8 °C for short-term use (up to 7 days). For longer-term storage, aliquot and freeze at −20 °C. Avoid repeated freeze–thaw cycles, as each cycle can degrade peptide integrity through aggregation and deamidation.

What solvents are recommended for reconstituting Semax?
+

Semax is soluble in sterile water (≥18 MΩ·cm resistivity), phosphate-buffered saline (PBS), or dilute acetic acid (0.1–1% v/v). A recommended starting concentration is ≥100 µg/mL before further dilution in aqueous experimental buffers. For solutions stored beyond 24–48 hours, adding 0.1% BSA or HSA as a carrier protein can help prevent peptide adsorption to vessel walls. Avoid DMSO for aqueous cell-based assays.

What is the difference between Semax and N-Acetyl Semax?
+

Standard Semax has the sequence Met-Glu-His-Phe-Pro-Gly-Pro. N-Acetyl Semax adds an acetyl group to the N-terminal methionine (Ac-Met-Glu-His-Phe-Pro-Gly-Pro). Acetylation reduces affinity for competing metal ions at the N-terminus and, in preclinical pharmacokinetics modelling, is associated with improved enzymatic stability and potentially extended experimental half-life in biological matrices. Researchers select between variants based on assay-specific stability requirements.

Is Semax a controlled substance in the United States?
+

As of April 2026, Semax is not scheduled under the US Controlled Substances Act (DEA) and is not approved by the FDA to treat, prevent, or cure any medical condition. PureRawz sells Semax exclusively as a research reagent for in-vitro laboratory use by qualified researchers. Regulations are subject to change — always verify current regulatory status with your institution's compliance office before purchasing or handling.

Does PureRawz offer bulk or institutional purchasing for Semax?
+

Yes. Academic institutions, contract research organisations (CROs), and qualified research organisations may contact PureRawz for bulk pricing, custom lot sizes, and institutional invoicing. All bulk orders include the same dual COA quality assurance (HPLC purity + LAL endotoxin) as standard orders. Reach out via the contact page for a custom quote.

Scientific Literature

References

Medvedeva EV et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia. BMC Genomics. 2014;15:228. doi:10.1186/1471-2164-15-228
Gusev EI et al. The efficacy of semax in the treatment of patients at different stages of ischemic stroke. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3):61–68. doi:10.17116/jnevro20181183261-68
Lebedeva IS et al. Effects of Semax on the Default Mode Network of the Brain. Bull Exp Biol Med. 2018;165(5):653–656. doi:10.1007/s10517-018-4234-3
Mars RB et al. On the relationship between the "default mode network" and the "social brain". Front Hum Neurosci. 2012;6:189. doi:10.3389/fnhum.2012.00189
Agapova TIu et al. Mol Gen Mikrobiol Virusol. 2008;(3):28–32. PMID: 18756811
Scantlebury MH et al. ACTH protects learning and memory function in epileptic Kcna1-null mice. Neurosci Lett. 2017;645:14–18. doi:10.1016/j.neulet.2017.02.069
Glazova NY et al. Semax attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure. Neuropeptides. 2021;86:102114. doi:10.1016/j.npep.2020.102114
Eremin KO et al. Semax activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005;30(12):1493–1500. doi:10.1007/s11064-005-8826-8
Kost NV et al. Semax and selank inhibit the enkephalin-degrading enzymes from human serum. Bioorg Khim. 2001;27(3):180–183. PMID: 11443939

⚠ Research Use Only — Full Disclaimer: All PureRawz products, including Semax, are furnished for in-vitro laboratory research purposes only. These products are not medicines, pharmaceuticals, or dietary supplements. They have not been approved by the US Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any medical condition, disease, or ailment. Bodily introduction of any kind into humans or animals is strictly prohibited by law. All purchases are limited to licensed researchers and qualified professionals. Any information provided on this page is for scientific and educational purposes only and does not constitute medical, clinical, veterinary, or professional advice. Full Terms & Conditions →