What is a dual COA and why does PureRawz provide one when competitors don't?

A dual COA means PureRawz provides two independent Certificates of Analysis per lot: (1) HPLC purity confirming ≥99% chemical identity, and (2) LAL endotoxin assay confirming bacterial LPS levels. Biotech Peptides provides HPLC, LC, and MS images but no LAL endotoxin data. ProSpec provides only RP-HPLC at 97% purity with no endotoxin testing. Endotoxin contamination at sub-nanogram levels activates TLR4 and destroys immune and inflammatory research assays.

Does PureRawz offer bulk purchasing for Selank?

Yes. Academic institutions and CROs may contact PureRawz for bulk pricing, custom lot sizes, and institutional invoicing. All bulk orders include the same dual COA (HPLC purity + LAL endotoxin) and unique lot traceability as standard orders.

N-Acetyl-Selank Amidate

Earn 32 – 158 points upon purchasing this product.

✅ 99% Purity – Third-Party Tested

🚚 Free U.S. Shipping on Orders $100+

🇺🇸 Proudly Made in the USA

⚡ Fast & Reliable Shipping

🔒 Secure Checkout Guaranteed

Enjoy 24/7 customer support, 1st & 3rd party verified 99% purity, and free shipping on orders over $100!

Category: Nootropics

Description
Reviews (0)

Buy Selank | ≥99% Pure | Dual COA | PureRawz USA

⚠ RESEARCH USE ONLY: All PureRawz products are strictly for in-vitro laboratory research. Not for human or animal consumption. Not FDA-approved. For use by qualified researchers only.
Full disclaimer ↓

≥99% Purity — HPLC Verified

Dual COA — HPLC + LAL Endotoxin

Unique Lot Numbers — Full Traceability

USA Manufactured & Third-Party Tested

Ships USA in 1 Business Day

✓ HPLC COA

✓ LAL COA

[Replace with product photo]

Lot: SL-2025-0312
QC: 2025-10-02
≥99.1% HPLC

Research Peptide · Tuftsin Analog · Anxiolytic

Buy Selank —
≥99% Purity + Dual COA

When you buy Selank from PureRawz, every vial arrives with two independent Certificates of Analysis — HPLC purity verification and an LAL endotoxin assay — traceable to a unique batch lot number. ProSpec only certifies 97% purity with no endotoxin data. Biotech Peptides provides no LAL testing either. PureRawz is different. USA-manufactured, third-party tested, ships in 1 business day. No prescription required.

≥99% HPLC Purity
LAL Endotoxin Tested
Unique Lot Number
USA Manufactured
Ships in 1 Business Day

$[PRICE]
per vial · free shipping $[THRESHOLD]+

Add to Cart

View Both COAs

In-stock orders ship same business day — USA domestic only

Technical Data

Full Product Specifications

All data verifiable via lot-specific COA documents included with every order.

Compound Name	Selank (TP-7)
Synonyms	Tuftsin-Pro-Gly-Pro, TP-7, Selanc
Amino Acid Sequence	Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight	751.88 g/mol
CAS Number	129954-34-3
Purity (HPLC)	≥99% — third-party verified per lot
Endotoxin (LAL)	Tested — COA included per lot
Physical Form	Lyophilised (freeze-dried) white powder
Solubility	Sterile water, PBS, or dilute acetic acid (0.1–1%)
Storage — Lyophilised	−20 °C, desiccated, protected from light
Storage — Reconstituted	2–8 °C short-term (≤7 d); −20 °C long-term
Stability	12–24 months lyophilised at −20 °C
Lot Traceability	Unique lot number — every vial, every batch
Manufacturing	USA (domestic synthesis and lyophilisation)
Testing	Independent third-party laboratory
Shipping	1 business day · USA domestic only
Intended Use	In-vitro laboratory research only

Quality Assurance

Why PureRawz Provides a Dual COA — And Why It Matters for Selank Research

ProSpec certifies only 97% purity by RP-HPLC with zero endotoxin data. Biotech Peptides shows HPLC and MS images but no LAL assay. PureRawz provides two separate, lot-specific Certificates of Analysis on every batch — because Selank's primary research applications (GABAergic modulation, immune signalling, cytokine assays) are exactly the assays that endotoxin contamination destroys most silently.

HPLC Purity Certificate

High-Performance Liquid Chromatography separates and quantifies every molecular species in the sample. PureRawz Selank consistently measures ≥99% purity per lot — compared to ProSpec's 97% RP-HPLC standard. The full chromatogram with peak integration is available in the COA PDF, confirming chemical identity and ruling out synthesis by-products or racemisation impurities.

≥99% purity confirmed per lot

LAL Endotoxin Assay Certificate

The Limulus Amebocyte Lysate (LAL) assay detects bacterial lipopolysaccharides (LPS) that HPLC cannot identify. This matters critically for Selank research: Selank is studied precisely for its interactions with IL-6 cytokine expression, immune cell modulation, and inflammatory gene pathways — all of which are catastrophically confounded by trace LPS contamination activating TLR4 at sub-nanogram levels. Neither competitor provides this test.

LAL endotoxin tested — per lot

Both COA documents are lot-number-specific. Download from the product page or retrieve via officialpurerawz.us/verify.

Research Background

What Is Selank?

Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It was rationally designed as a metabolically stable analog of tuftsin — a naturally occurring immunoregulatory tetrapeptide (Thr-Lys-Pro-Arg) found in the heavy chain of human immunoglobulin G (IgG). Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in collaboration with the V.V. Zakusov Research Institute of Pharmacology, Moscow.

The C-terminal Pro-Gly-Pro (PGP) tripeptide extension — the same structural motif found in Semax — serves two purposes in preclinical research: it enhances the peptide's metabolic stability against enzymatic degradation, and it is hypothesised to facilitate central nervous system delivery via lipid raft-mediated and receptor-mediated transcytosis mechanisms at the blood–brain barrier. Without this extension, the parent tuftsin tetrapeptide is rapidly degraded by serum carboxypeptidases.

Selank has completed Phase III clinical trials in Russia for generalised anxiety disorder and neurasthenia, where it is approved as a 0.15% intranasal formulation under the name Selank. As of April 2026, it is not FDA-approved for any use in the United States and is sold by PureRawz exclusively as an in-vitro research reagent. All preclinical findings cited on this page arise from animal or cell-based models.

In published literature, Selank is studied across five primary research domains: GABAergic neurotransmission, BDNF expression and neurotrophin modulation, enkephalin-degrading enzyme inhibition, serotonergic and dopaminergic pathway interactions, and immune system gene expression. Its pharmacological distinction from classical benzodiazepines — anxiolytic activity without sedation, tolerance, or dependence in preclinical models — makes it a useful tool for dissecting these pathways independently.

Mechanistic Science

Mechanism of Action — Six Research Pathways

Peer-reviewed preclinical literature has characterised at least six distinct molecular pathways. All findings are from in-vitro or animal studies only.

GABAergic System Modulation (GABA-A Allosteric)

Selank allosterically modulates GABA-A receptors, increasing inhibitory GABA neurotransmission. Real-time PCR analysis of 84 neurotransmission genes in rat frontal cortex found significant expression changes in 45 genes at 1 h post-administration, with a strong positive correlation between Selank and exogenous GABA effects — positioning Selank as a non-classical GABA-A receptor modulator.

Volkova et al., Front Pharmacol 2016 [1]; Kasian et al., Behav Neurol 2017 [2]

BDNF Upregulation & Neurotrophin Modulation

Selank has been shown to upregulate BDNF mRNA in the rat hippocampus and prefrontal cortex following intranasal administration. In models of ethanol-induced memory impairment, Selank's cognitive-protective effects correlated directly with BDNF content normalisation in these regions — connecting the neurotrophin axis to the peptide's nootropic profile.

Inozemtseva et al., 2008; Kolik et al., Bull Exp Biol Med 2019 [6]

Enkephalin-Degrading Enzyme Inhibition

Selank inhibits enkephalinase — the serine protease responsible for breaking down enkephalins in serum and CNS tissue. By extending the half-life of leu-enkephalin (particularly in anxiety models), Selank may preserve endogenous opioidergic tone and its downstream modulation of dopaminergic and serotonergic pathway crosstalk — without directly binding opioid receptors.

Zozulya et al., Bull Exp Biol Med 2001; Meshavkin et al., 2006 [3]

Serotonergic System Modulation

Selank modulates serotonin metabolism, particularly in brainstem regions linked to mood and anxiety regulation. Studies in murine models with inhibited serotonin synthesis demonstrate that Selank can restore serotonergic function. Selank also modulates serotonin receptor expression, providing a distinct neurochemical mechanism complementary to its GABAergic activity.

Semenova et al., Exp Klin Farmakol 2010 [8]

Immune System Gene Expression (IL-6, Cytokine, Chemokine)

Selank affects the expression of approximately 34 genes in inflammatory pathways, including those encoding chemokines, cytokines, and their receptors. It has been studied for inhibition of IL-6 gene expression in depression models (but not control models), modulation of Bcl6 (an immune development transcription factor), and transient expression changes for C3, Casp1, Il2rf, and Xcr1 in mouse spleen tissue.

Uchakina et al., Zh Nevrol Psikhiatr 2008 [4]

Lipid Metabolism & Hemostasis Modulation

In murine models of experimental metabolic syndrome, Selank exposure was associated with reductions in cholesterol and lipid levels of approximately 25–58%, including LDL, VLDL, and triglycerides. Hemostasis readouts showed increased total fibrinolytic activity and reduced platelet aggregation. These metabolic findings open a distinct research dimension not commonly studied in peptide anxiolytic research.

Mjasoedov et al., Hemostasis & Lipid Profile 2014 [7]

Unique to PureRawz

Batch Traceability — Our Public Lot Verification Portal

Biotech Peptides shows generic COA images on their product page. ProSpec ships at room temperature with 97% purity and no endotoxin data. Neither offers batch-level public traceability. PureRawz does — because researchers need to verify what they received, not just trust a label.

Every vial is traceable to a specific, independently tested batch.

Our lot numbering system encodes the compound code, synthesis batch number, and QC release date. Every lot is indexed in our public verification portal — enter the lot number printed on your vial at officialpurerawz.us/verify and retrieve:

The HPLC purity COA PDF for your exact batch
The LAL endotoxin COA PDF for your exact batch
The name of the independent third-party testing laboratory
The QC release date and synthesis batch ID
Documentation suitable for IRB submissions and publication methodology sections

Sample Lot Number

SL-2025-0312

Compound: Selank
Batch: #312 · QC Released
Purity: ≥99.1% HPLC

Verify at /verify →

Supplier Comparison

PureRawz vs. Competitors — Selank Side-by-Side

Based on publicly available supplier information as of April 2026.

Feature	PureRawz ✦	Biotech Peptides	ProSpec Bio
Purity Standard	≥99% HPLC	99% (claimed)	Only 97% RP-HPLC
HPLC Purity COA	✔ Per lot	✔ Images on page	✔ RP-HPLC only
LAL Endotoxin COA	✔ Per lot — full assay	✗ Not provided	✗ Not provided
Mass Spec (MS) Verification	✔ Per lot	✔ Images on page	✗ Not stated
Unique Lot Number Per Vial	✔ Every vial	Partial	✗ Not mentioned
Public Lot Verification Portal	✔ officialpurerawz.us/verify	✗	✗
USA Manufactured	✔	✔	✗ Israel-based
Ships in 1 Business Day (USA)	✔	✔ Same-day by 12 PST	✗ International shipping
No Prescription Required	✔	✔	✔
Trust Badges on Page	✔ 5 badges	✗ None visible	✗ None
FAQ Section (Rich Results)	✔ 10 schema Q&As	✗	✗
PubMed-Linked References	✔ 10 cited	✔ 12 cited	✗ No references
Shipping Temperature Control	✔ Cold-chain capable	✔	✗ Room temp shipping

✦ PureRawz. Data from publicly available pages, April 2026. Subject to change.

Related Research Compounds

Researchers Studying Selank Also Explore

Frequently Asked Questions

Selank Research FAQ

For research and educational purposes only. Nothing here constitutes medical advice.

What is Selank and what is it used for in research?+

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro; CAS 129954-34-3) is a synthetic heptapeptide analog of tuftsin developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. In laboratory settings, it is studied for GABAergic system modulation (GABA-A allosteric activity), BDNF upregulation in hippocampal and prefrontal cortex tissue, enkephalin-degrading enzyme inhibition, serotonergic/dopaminergic pathway interactions, immune gene expression modulation (IL-6, cytokines, chemokines), and nootropic effects in preclinical rodent models. All research use is strictly in-vitro or preclinical.

What purity does PureRawz Selank have, and how does it compare to competitors?+

PureRawz Selank is manufactured to ≥99% purity as measured by HPLC on a per-lot basis by an independent third-party laboratory. By comparison, ProSpec (competitor #2) only certifies 97% purity by RP-HPLC — a meaningful difference for sensitive assays. Biotech Peptides claims 99% but provides HPLC/MS images rather than downloadable lot-specific COA documents. PureRawz provides the full chromatogram PDF plus a separate LAL endotoxin COA per lot.

What is a dual COA and why is it especially important for Selank research?+

A dual COA means PureRawz provides two independent, lot-specific Certificates of Analysis: (1) HPLC purity confirming ≥99% chemical identity, and (2) LAL endotoxin assay confirming bacterial LPS levels. This is especially critical for Selank research because Selank is studied for immune system modulation — IL-6 expression, cytokine pathways, and immune gene clusters. These are precisely the assays most destroyed by trace endotoxin contamination, as sub-nanogram LPS activates TLR4 on macrophages and generates massive false-positive cytokine signals. Neither Biotech Peptides nor ProSpec provides LAL data.

How does PureRawz's lot number traceability system work?+

Every PureRawz vial carries a unique lot number encoding the compound identifier, synthesis batch number, and QC release date. Enter that lot number at officialpurerawz.us/verify to retrieve both the HPLC purity COA and the LAL endotoxin COA for your specific batch, along with the testing laboratory's name and QC release date. This is useful for IRB submissions, grant applications, and publication methodology sections requiring reagent provenance documentation.

How quickly does PureRawz ship Selank, and where do you ship?+

All in-stock PureRawz orders ship within 1 US business day from our domestic USA facility. Tracking information is provided automatically upon dispatch. We ship exclusively within the United States. ProSpec Bio, by contrast, is Israel-based and ships internationally, adding transit time and customs risk for US-based labs. No prescription or institutional affiliation is required to purchase Selank from PureRawz.

How should I store lyophilised Selank in my laboratory?+

Store lyophilised Selank at −20 °C or below, in a sealed desiccated container away from light and moisture. Under these conditions, lyophilised peptides are typically stable for 12–24 months. Note: ProSpec states their product is stable at room temperature for only 3 weeks — significantly less stable than properly stored lyophilised peptide. Once reconstituted, store at 2–8 °C for up to 7 days, or aliquot and freeze at −20 °C. Avoid repeated freeze-thaw cycles.

What solvents are recommended for reconstituting Selank?+

Selank dissolves in sterile water (≥18 MΩ·cm), phosphate-buffered saline (PBS), or dilute acetic acid (0.1–1% v/v). Recommended starting concentration is ≥100 µg/mL before further dilution. For solutions stored beyond 24–48 hours, adding 0.1% BSA or HSA as a carrier protein prevents peptide adsorption to vessel walls. ProSpec recommends the same reconstitution approach, noting that carrier protein addition is especially important for long-term stored solutions.

What is the difference between Selank and Semax?+

Both Selank and Semax are synthetic heptapeptides sharing the C-terminal Pro-Gly-Pro extension and both inhibit enkephalin-degrading enzymes. However, their parent sequences and primary research applications differ significantly. Selank (tuftsin analog: Thr-Lys-Pro-Arg-PGP) is studied primarily for GABAergic modulation and anxiolytic activity without sedation. Semax (ACTH 4-7 analog: Met-Glu-His-Phe-PGP) is studied primarily for neurotrophic BDNF/NGF signalling and neuroprotection in ischaemia models. They are frequently purchased together as complementary research tools for studying anxiety versus neuroprotection mechanisms.

Is Selank a controlled substance in the United States?+

As of April 2026, Selank is not scheduled under the US Controlled Substances Act (DEA) and is not FDA-approved for any medical use in the United States. It is approved in Russia as a 0.15% intranasal formulation for generalised anxiety disorder and neurasthenia. PureRawz sells Selank exclusively as an in-vitro research reagent for qualified researchers. Always verify current regulatory status with your institution's compliance office before purchasing or handling.

Does PureRawz offer bulk or institutional purchasing for Selank?+

Yes. Academic institutions, contract research organisations (CROs), and qualified research organisations may contact PureRawz for bulk pricing, custom lot sizes, and institutional invoicing. All bulk orders carry the same dual COA quality assurance (HPLC purity + LAL endotoxin) and unique lot traceability as standard orders. Contact our research team via the support page for a custom quote.

Scientific Literature

References

Volkova A et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31. doi:10.3389/fphar.2016.00031. PMID: 26924987
Kasian A et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027. doi:10.1155/2017/5091027. PMID: 28280289
Sokolov OY et al. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice. Bull Exp Biol Med. 2002;133(2):133–135. doi:10.1023/a:1015582302311. PMID: 12432865
Uchakina ON et al. Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71–75. PMID: 18577961
Zozulia AA et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38–48. PMID: 18454096
Kolik LG et al. Selank protects against ethanol-induced memory impairment by regulating BDNF content in the hippocampus and prefrontal cortex in rats. Bull Exp Biol Med. 2019;167(5):641–644. PMID: 31625062
Mjasoedov NF et al. The Influence of Selank on the Parameters of the Hemostasis System, Lipid Profile, and Blood Sugar Level in the Course of Experimental Metabolic Syndrome. 2014.
Semenova TP et al. Experimental optimization of learning and memory processes by selank. Eksp Klin Farmakol. 2010;73(8):2–5. PMID: 20919564
Shadrina MI et al. Expression analysis of Selank effect on the rat brain structures related to anxiety. Zh Vyssh Nerv Deiat Im I P Pavlova. 2010;60(4):476–483.
Shadrina MI et al. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front Pharmacol. 2017;8:89. doi:10.3389/fphar.2017.00089

⚠ Research Use Only — Full Disclaimer: All PureRawz products, including Selank, are furnished for in-vitro laboratory research purposes only. These products are not medicines, pharmaceuticals, or dietary supplements. They have not been approved by the US Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any medical condition, disease, or ailment. Bodily introduction of any kind into humans or animals is strictly prohibited by law. All purchases are limited to licensed researchers and qualified professionals. Any information provided on this page is for scientific and educational purposes only and does not constitute medical, clinical, veterinary, or professional advice. Full Terms & Conditions →

Buy Selank

Selank is a popular nootropic research peptide commonly explored for mood support, cognitive studies, anxiety research, and advanced laboratory applications.
Browse related Purerawz products and trusted scientific references below.

Research References

PubMed Research Database
– scientific studies and published research
National Center for Biotechnology Information (NCBI)
– biomedical and research resources
U.S. Food and Drug Administration
– regulatory and compliance reference

Reviews

There are no reviews yet.

Be the first to review “N-Acetyl-Selank Amidate”

Reviews

Be the first to review “N-Acetyl-Selank Amidate”

N-Acetyl-Selank Amidate

Buy Selank —
≥99% Purity + Dual COA

Full Product Specifications