Ibutamoren (MK-677)
Price range: $60.67 through $144.82
Earn 34 – 192 points upon purchasing this product.
✅ 99% Purity – Third-Party Tested
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Buy MK-677 (Ibutamoren Mesylate)
≥99% HPLC · Dual COA · USA Made
MK-677 is the most studied oral GH secretagogue in clinical research — which makes source documentation non-negotiable for reproducible GHSR, GH, and IGF-1 pathway studies. Adooq lists >99% HPLC purity but gates their QC report behind a form request with no LAL endotoxin data published. SwissChems (Iceland-registered) shows no purity figure on their capsule page and states results are only "occasionally published." PureRawz supplies ≥99% HPLC-verified MK-677 Mesylate with a dual COA — HPLC and LAL endotoxin — instantly verifiable by unique lot number at /verify, shipped from the USA in 1 business day.
LAL Endotoxin Tested
Unique Lot Per Vial
USA Manufactured
No Rx Required
Full Specifications
Comprehensive compound data for MK-677 (Ibutamoren Mesylate) as supplied by PureRawz. Batch-specific analytical values are documented on each COA.
| Compound Name | MK-677 (Ibutamoren Mesylate, Nutrobal, L-163,191) |
| Common Synonyms | Ibutamoren Mesylate; MK-0677; L-163,191; Crescendo; Nutrobal; 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide methanesulfonate |
| Salt Form | Mesylate salt (CAS 159752-10-0) — preferred form in 90%+ of peer-reviewed literature |
| Free Base CAS | 159634-47-6 |
| Molecular Formula | C₂₇H₃₆N₄O₅S · CH₄O₃S (Mesylate salt) |
| Molecular Weight | 624.77 g/mol (Mesylate salt) |
| CAS Number | 159752-10-0 (Mesylate) |
| Target Receptor | Growth Hormone Secretagogue Receptor 1a (GHS-R1a / GHSR) |
| HPLC Purity | ≥99% (HPLC — UV detection, per-lot certificate) |
| Endotoxin Status | LAL Endotoxin Tested — Certificate Provided (Dual COA) |
| Physical Form | Crystalline solid (white to off-white powder) · Hygroscopic — store desiccated |
| Solubility | DMSO: ≥50 mg/ml · Water/PBS: ~1–5 mg/ml (Mesylate salt, good aqueous solubility) · Ethanol: moderate |
| Storage Conditions | –20°C solid, desiccated, sealed from light and moisture · Reconstituted: –20°C (1 month) or –80°C (6 months) |
| Stability (Solid) | ≥3 years at –20°C · Mesylate salt more stable than free base · Avoid repeated freeze-thaw |
| Lot Traceability | Unique lot number per vial · Full dual COA retrievable at officialpurerawz.us/verify |
| Manufacturing Location | United States of America · Third-party analytical verification |
| Shipping Speed | Dispatched within 1 business day · USA domestic only |
| Intended Use | In vitro and in vivo laboratory research only · Not for human or veterinary use |
| Prescription Required | No · Research purchase, no Rx needed in USA |
Dual Certificate of Analysis
Two independent analytical certifications are issued for every PureRawz MK-677 lot — instantly retrievable by unique lot number, no form required.
HPLC Purity Certificate
High-Performance Liquid Chromatography with UV detection confirms compound identity and quantifies every detectable impurity in the sample. PureRawz HPLC analysis produces a full chromatogram with retention time matched against certified Ibutamoren Mesylate reference standards — performed on your specific production lot number, not a representative batch sample.
- Purity ≥99% guaranteed on every lot — a minimum floor verified by independent HPLC analysis
- Full UV chromatogram instantly retrievable at /verify with your unique lot number — zero form required
- Confirms Mesylate salt identity; detects free base adulteration or degradation products
- Adooq: >99% purity stated — but QC report requires a form request, no instant public access
LAL Endotoxin Certificate
The Limulus Amebocyte Lysate (LAL) assay is the FDA-recognized gold standard for bacterial endotoxin (LPS) detection. HPLC is completely insensitive to endotoxins. MK-677 is especially vulnerable to endotoxin confounds — GHS-R1a is co-expressed with TLR4 signalling components in hypothalamic and pituitary cells. Sub-nanogram LPS activates TLR4 → NF-κB, suppresses GH pulsatility, elevates basal IL-1β and IL-6, and invalidates every GH secretion, GHSR binding, and IGF-1 elevation assay in the experiment.
- LAL endotoxin result expressed in EU/ml — per-lot certificate included with every order
- Mandatory for GHSR binding, GH secretion, IGF-1 upregulation, and sleep architecture studies
- Suitable for IRB, IACUC, and institutional biosafety committee protocol documentation
- Prevents LPS-driven false-negative GH secretion and false-positive inflammatory readouts
Mechanism of Action
MK-677 is a non-peptide, orally active ghrelin receptor agonist and growth hormone secretagogue. Six primary pharmacological pathways are documented below.
GHS-R1a (GHSR) Selective Agonism
MK-677 binds selectively and potently to the growth hormone secretagogue receptor 1a (GHS-R1a / GHSR), mimicking the action of endogenous ghrelin. Unlike ghrelin, MK-677 is orally bioavailable and resistant to proteolytic degradation, producing sustained GHSR activation in arcuate and ventromedial hypothalamic neurons. This makes it the primary research tool for studying GHSR-mediated signalling pathways without the instability limitations of native ghrelin peptide.
GH Pulsatile Secretion Amplification
GHSR activation by MK-677 in somatotroph cells of the anterior pituitary amplifies both pulsatile GH release amplitude and interpulse GH trough levels, driving sustained increases in plasma GH concentrations. This mechanism is mediated by GHSR-coupled Gαq/11 signalling → phospholipase C activation → IP3-triggered intracellular Ca²⁺ mobilization → exocytosis of somatotroph secretory granules. MK-677 does not affect cortisol levels, providing a clean model for isolated GH-axis research.
IGF-1 Elevation via GH-Liver Axis
GH secreted under MK-677 stimulation circulates to the liver, binding GH receptors and activating JAK2/STAT5 signalling to drive transcription of the IGF-1 gene. This results in sustained, dose-dependent increases in circulating IGF-1 levels that persist throughout multi-week treatment periods. IGF-1 then acts on peripheral tissues through IGF-1R → PI3K/Akt/mTOR and Ras/MAPK pathways, producing anabolic, neuroprotective, and bone-protective downstream effects.
Muscle Protein Synthesis and Anti-Catabolic Effects
MK-677-driven GH and IGF-1 elevations promote skeletal muscle anabolism by activating PI3K/Akt/mTOR in myocytes, driving protein synthesis while concurrently suppressing proteasomal degradation pathways. In Phase II clinical trials targeting hip fracture and cachexia patients, MK-677 demonstrated statistically significant increases in lean body mass and reductions in urinary creatinine — markers of net anabolic muscle protein balance — establishing it as the reference compound for GH secretagogue muscle anabolism research.
Neuroprotection and Cognitive Pathway Research
GHSR is expressed broadly in brain regions governing appetite, memory, mood, and cognition — including the hippocampus, amygdala, and prefrontal cortex. In 5XFAD Alzheimer's mouse models, MK-677 administration significantly preserved NeuN-positive neurons and synaptic immunoreactivity markers (SYN) in the neocortex versus vehicle-treated controls. These neuroprotective effects are attributed to GH/IGF-1 axis activation of BDNF expression and Akt-mediated anti-apoptotic signalling.
Sleep Architecture Modulation via GHSR
GHSR activation in hypothalamic sleep-wake regulation centres by MK-677 increases REM sleep duration and slow-wave (stage IV) sleep in research subjects. GH secretion is physiologically coupled to slow-wave sleep onset, and MK-677 amplifies this coupling by augmenting nocturnal GH pulse amplitude. This pathway is studied in models of age-related GH decline, sleep disorder pharmacology, and GH-sleep axis interaction research.
Lot Verification Portal
Every PureRawz MK-677 vial carries a unique lot number linked to its own dual COA. Adooq requires a form. SwissChems publishes results occasionally. PureRawz gives you instant, lot-specific, public access — always.
HPLC Chromatogram
Full UV trace with peak identification for your exact MK-677 Mesylate production lot.
LAL Endotoxin Report
Numerical EU/ml result and methodology for your specific lot — instant, no form.
Manufacturing Chain
Lot issuance date, USA manufacturing location, and third-party testing lab reference.
IRB-Ready Documentation
COA formatted for institutional review board and IACUC protocol submissions.
Publication Support
Lot-specific data ready for materials & methods sections of peer-reviewed journals.
Tamper-Evident Traceability
Each lot number uniquely and immutably linked — no shared or duplicated batch assignments.
How PureRawz Compares
An objective comparison of data publicly available on each supplier's MK-677 product page as of April 2026.
| Criteria | PureRawz | Adooq | SwissChems (Capsule) |
|---|---|---|---|
| HPLC Purity Claim | ≥99% | >99% (stated) | Not stated on capsule page |
| HPLC COA Accessible | ✓ Instant via /verify | ✗ Form/email request required | ✗ "Occasionally published" — not per-lot |
| LAL Endotoxin COA | ✓ Per lot, public | ✗ Not listed on product page | ✗ Not listed |
| Unique Lot # Per Vial | ✓ Yes | Catalog batch system | ✗ Not stated |
| Public Lot Verification Portal | ✓ /verify | ✗ No public portal | Product verify page (batch — not lot) |
| USA Based / Manufactured | ✓ USA | ✗ China-based | ✗ Iceland-registered (.is domain) |
| Salt Form | Mesylate (CAS 159752-10-0) | Mesylate (CAS 159752-10-0) | Not specified on product page |
| Shipping Speed | 1 business day (USA) | 7–14 days (China origin) | Same-day if ordered before 12 PM EST |
| No Rx Required | ✓ Yes | Research accounts — no patient sales | ✓ Yes |
| Trust Badges on Page | 5 badges | Research use disclaimer only | Safe checkout badge · 7-day return |
| FAQ Section on Page | ✓ 10 Q&As + schema | ✗ No | ✗ No (separate FAQs page only) |
| PubMed References on Page | ✓ 6 linked | References listed but not inline | ✗ None on product page |
| FAQPage Schema Markup | ✓ Full JSON-LD | ✗ No | ✗ No |
MK-677 (Ibutamoren) Research FAQ
Answers to the most common questions researchers ask before purchasing MK-677 from PureRawz.
PubMed-Linked References
This page cites peer-reviewed research available in the National Library of Medicine's PubMed database.
-
[1]
Chapman IM, Bach MA, Van Cauter E, et al. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab. 1996;81(12):4249-57. PMID 9400006 ↗ -
[2]
Copinschi G, Leproult R, Van Onderbergen A, et al. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. 1997;66(4):278-86. PMID 9771867 ↗ -
[3]
Adunsky A, Chandler J, Heyden N, et al. MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Arch Gerontol Geriatr. 2011;53(2):183-9. PMID 21067829 ↗ -
[4]
Jeong YO, Shin SJ, Park JY, et al. MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer's Disease. Int J Mol Sci. 2018;19(6):1800. PMID 29899142 ↗ -
[5]
Bach MA, Rockwood K, Zetterberg C, et al. The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. J Am Geriatr Soc. 2004;52(4):516-23. PMID 15066065 ↗ -
[6]
Nass R, Pezzoli SS, Oliveri MC, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. Ann Intern Med. 2008;149(9):601-11. Long-term GH/IGF-1 elevation and body composition effects of MK-677. PMID 18981485 ↗
RESEARCH USE ONLY DISCLAIMER: All products sold by PureRawz (officialpurerawz.us) are intended exclusively for in vitro and in vivo scientific research by trained laboratory personnel. MK-677 (Ibutamoren Mesylate) is NOT approved by the Food and Drug Administration (FDA) for human use. It is NOT a dietary supplement, pharmaceutical drug, or therapeutic agent. It is NOT intended for human consumption, self-administration, or veterinary use. PureRawz makes no medical claims and all information on this page is provided for educational and research reference purposes only. Researchers are solely responsible for compliance with all applicable institutional, federal, state, and international regulations governing the purchase, handling, and use of research chemicals. By purchasing from PureRawz, the buyer confirms they are a qualified research professional and that the compound will be used only for legitimate scientific research purposes.
Buy MK-677
MK-677 is a widely researched growth hormone secretagogue commonly explored for recovery studies, muscle support, sleep research, and advanced laboratory applications.
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Research References
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PubMed Research Database
– scientific studies and published research -
National Center for Biotechnology Information (NCBI)
– biomedical and research resources -
U.S. Food and Drug Administration
– regulatory and compliance reference
Additional information
| Attribute | Powder 1g, Injectables 10ml/64mg per ml = 640mg, Tablets 20mg/27ct/540mg, Capsules 20mg / 60ct / 1.2g |
|---|
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